KannaLife Prospective Grant

FEDERAL REGISTER: The Daily Journal of the United States Government.

Prospective Grant of Exclusive License: Development of Cannabinoid(s) and Cannabidiol(s) Based Therapeutics To Treat Hepatic Encephalopathy in Humans.

A Notice by the National Institutes of Health on 11/17/2011


This is notice, in accordance with 35 U.S.C. 209(c)(1) and 37 CFR part 404.7(a)(1)(i), that the National Institutes of Health, Department of Health and Human Services, is contemplating the grant of an exclusive patent license to practice the invention embodied in U.S. Patent 6,630,507, entitled “Cannabinoids as antioxidants and neuroprotectants” and PCT Application Serial No. PCT/US99/08769 and foreign equivalents thereof, entitled “Cannabinoids as antioxidants and neuroprotectants” [HHS Ref. No. E-287-1997/2] to KannaLife Sciences Inc., which has offices in New York, U.S.

This patent and its foreign counterparts have been assigned to the Government of the United States of America.

The prospective exclusive license territory may be worldwide, and the field of use may be limited to:

The development and sale of cannabinoid(s) and cannabidiol(s) based therapeutics as antioxidants and neuroprotectants for use and delivery in humans, for the treatment of hepatic encephalopathy, as claimed in the Licensed Patent Rights.

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Reference: http://en.wikipedia.org/wiki/Hepatic_encephalopathy

KannaLife Sciences Inc.

KannaLife Sciences, Inc. is a socially responsible, developmental stage phyto-medical/bio-pharmaceutical company that specializes in the research, development, and packaging of pharmacological products derived from botanical sources, including the cannabis taxa. KannaLife’s plan for generating revenue and growth is intended to come from (i.) KannaLife’s proprietary branding POS and hermetic packaging systems for the medical marijuana industry; (ii.) KannaLife’s branded anti-oxidant and recovery skin care ointments and creams; and (iii.) the development, marketing and sale of KannaLife biopharmaceutical and phyto-pharmaceutical products derived from cannabis for the treatment of patients suffering with neuro-degenerative, neuro-toxic and oxidative stress related diseases and disorders.

The Company’s focus on product development was born from the burgeoning market in the United States in the use of traditional healthcare models of treatment, utilizing medicinal marijuana and other APIs found in the genus of the cannabis taxa.

KannaLife intends to profit from the acquisition, development, marketing and sale of phyto-medical drugs and products derived from cannabinol (“CBN”) and cannabidiol (“CBD”) compounds as art and parcel to the Company’s drug development plan. The disease indications to which the Company intends to target for the development of its products are centered on patients suffering from diseases with neuro-degenerative and/or neuro-toxic profiles.

In addition the Company has developed a unique “blue ocean” approach to participating in the fast growing multi-billion dollar medical marijuana industry in establishing a “Gold Standard” in QA for delivering a consistent and reliable product to the consumer for dispensing medicinal marijuana in hermetically sealed packaging.



The US Patent
Cannabinoids as antioxidants and neuroprotectants.


The present invention concerns pharmaceutical compounds and compositions that are useful as tissue protectants, such as neuroprotectants and cardioprotectants. The compounds and compositions may be used, for example, in the treatment of acute ischemic neurological insults or chronic neurodegenerative diseases.


Permanent injury to the central nervous system (CNS) occurs in a variety of medical conditions, and has been the subject of intense scientific scrutiny in recent years. It is known that the brain has high metabolic requirements, and that it can suffer permanent neurologic damage if deprived of sufficient oxygen (hypoxia) for even a few minutes. In the absence of oxygen (anoxia), mitochondrial production of ATP cannot meet the metabolic requirements of the brain, and tissue damage occurs. This process is exacerbated by neuronal release of the neurotransmitter glutamate, which stimulates NMDA (N-methyl-D-aspartate), AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionate) and kainate receptors. Activation of these receptors initiates calcium influx into the neurons, and production of reactive oxygen species, which are potent toxins that damage important cellular structures such as membranes, DNA and enzymes.

The brain has many redundant blood supplies, which means that its tissue is seldom completely deprived of oxygen, even during acute ischemic events caused by thromboembolic events or trauma. A combination of the injury of hypoxia with the added insult of glutamate toxicity is therefore believed to be ultimately responsible for cellular death. Hence if the additive insult of glutamate toxicity can be alleviated, neurological damage could also be lessened. Anti-oxidants and anti-inflammatory agents have been proposed to reduce damage, but they often have poor access to structures such as the brain (which are protected by the blood brain barrier).

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Further information on this issue and many more links visit;

Patented Pot vs. the Herbal Gold Standard: http://www.cannabisculture.com/v2/node/19879

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